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How Long Does It Take For Lupron Side Effects To Start

Lupron side effects

Joelhirsch profile image

I'm having a great deal of trouble with the side effects of the Lupron (and the enzalutamide). Likewise the heat flashes, I'1000 completely emotionally overwhelmed, sometimes over something, sometimes over nothing. And a complete lack of motivation. My oncologist has suggested anti-depressant, which I'chiliad resisting, but will likely agree if I tin't find another manner to manage it. Whatever suggestions would be appreciated. thank you in advance. By the way, I'm 55, DX 2 years agone. GS x, post radical, mail-chemo, in a written report with NIH that appears to be having a positive upshot on the CA, for now at least. But truthfully, I really don't intendance.

Joel,

It'due south easy to skid into the night side with pca. You demand to fight fight fight! That ways you try excercise, help groups, this lath, and yeah, if yous need a drug to aid, that besides!

All-time wishes

Hankm

Jvaughan0 profile image

Part of you lot cares about something. Focus on that part. This may not exist the life y'all envisioned, but there is still light and purpose.

Dan59 profile image

Joel, I did not realize there was so many of us Gleason 10 guys, welcome! It gets better, loss of T can make united states of america emotional also as a cancer dx, endeavour a fan for the hot flashes, and attempt to make the almost of every twenty-four hour period, walk, become out of the house, live your life, try to help others, all these things assistance. I was dxed as phase 4 witjh GS 10 back in 06. I am very curious what trial you are on that is showing do good, can you lot tell u.s., Cheers

Joelhirsch profile image

I'thou in a study, what comes before a trial. it involves enzalutamide and a serial of immunotherapy injections, ongoing. I'yard not certain, only if you've already been on the enz y'all might not be eligible, but I'grand not sure. NIH has a website where yous can plug in your illness and age and nix code and information technology gives you a list of studies and trials within a sure distance of you, I recall 100 miles. The 1 I'm in is actually at NIH in Bethesda, but there are a lot of NIH approved hospitals.

Thanks for your respond, and good luck.

Dan59 profile image

Thanks Joel, You are correct , I am probably non eligible, only I am e'er curious about the new immunotherapies every bit I believe that is the future, and when they get it right , it will benefit all of us.

Dan

Joelhirsch profile image

I don't know if you're eligible. You should call NIH.

YostConner profile image

I accept used antidepressants. Without them I accept mood swings and lash out at people I love. Currently using Cymbalta to practiced effect.

Based on my own experience, I would recommend medical marijuana if you are in a state that allows information technology. I use it for low when I need to and it works wonderfully with minimal side effects. It also helps with pain relief and indisposition, I've used it for both. Proficient luck.

Joelhirsch profile image

Thanks. Not legal in my state, just I couldn't intendance less. lol. what are they gonna do to me? I smoke a bit at dinner time or I wouldn't exist able to eat. never got my appetite dorsum later the chemo.

westseraph profile image

Gleason nine here. I wouldn't be able to eat without the medical cannabinoids. CBD is the substance in marijuana that brings back taste, helps with mood, helps go along down nausea and anxiety. I get it in a 25mg CBD to 1mg THC tincture, so we can administer in a dropper under my tongue. A little THC is necessary for CBD, but with my tincture I don't get high, just relaxed and peaceful. I've fought depression and anxiety. I've been able to relax and conquer with peace - able to breathe without a constant sense of battle. I'd say go for it if you can.

Saif786 profile image

Hey did u have hempseed cbd. Asking for dad. I bought some cbd

It'southward made with hemp seed oil infused with cbd. Would that be ok for him to accept

It's at 15mg cbd and .3 percent thc

Whatever cbd's Tout many benifits. I've taken them for 3yrs. I also washed strength thx oil for the same time. Annihilation that helps...

WSOPeddie profile image

I am partial to 'Blueish Dream'. Don't utilise it oftentimes and of grade never when I anticipate needing to drive somewhere. It is nice to live in a somewhat enlightened state.

Joelhirsch profile image

what is blue dream?

JamesAtlanta profile image

At that place are a lot of things that can assist with hot flashes. The all-time relief I take received was taking gabapentin. It helps me a lot. Tried accupuncture, but it did not aid much.

Equally for low, I suppose there are a number of options on a continuum. Exercise and forcing myself to stay active has worked well for me. I just experience better if I walk a few miles, become to the gym or ride my Pelaton. I accept to acknowledge I never want to. Simply I am always glad I did when it'southward over.

Yoga, meditation and acupuncture may aid, likewise. Or a support group.

But there is also no shame in taking an antidepressant. There is a reason the doctor asks every time we visit if we are having any depression. Information technology'due south of import to reply them truthfully and to go assist

Most chiefly, don't forget that the purpose of the Lupron is to help us alive longer, with some quality of life, then we tin can spend time doing what nosotros want to and to be with our loved ones.

I exercise hope you feel better and take the right action for you lot to get better. PcA is tough enough without another demon to bargain with. They can care for this one! 😊

Insightful & positive.Thank you!

pkafka profile image

I could sense that mild low was messing up my relationships with my family and friends. I found the mild anti-depressant, "Wellbutrin" helped me quite a fleck to even out y emotional swings. As well I strongly urge you to get into an do regimen, join a gym or find others you can piece of work out with on a regular basis to give you the umph to walk or work out. There is a certain level of lack of inertia that PCa and information technology's various treatments places on all of us and whatever we tin can do to overcome this boring lack of inertia is valuable. I have chosen to not go the medical marijuana road considering I recall from my "hippie" days that the drug did not help me overcome the land of remainder.

Pkafka

Reptale profile image

I'm older (72), but otherwise in a similar situation (GS 10, post radical, etc). Started Lupron 12/ane/2014 and now on Zytiga and Prednisone, also. Mood swings into bad low started for me almost ii years agone and my spouse who's a therapist suggested Celexa. Been taking it daily ever since. No side furnishings at all and afterward an initial couple of weeks, I don't even observe it anymore. I still get to feeling hopeless sometimes and deplorable well-nigh having CA, but I'm not having crying jags like I used to. My sense is that psychotropic drugs have come a long fashion from the early days and that you can get some emotional ease without feeling dopey and numb.

Hi Joel,

A lot of options from guys who have been at that place. I didn't realize the severe headaches I was having were from depression. My primary put me on Cymbalta, and just similar that I was felling better. I also take a marijuana product daily, since my diagnosis, and I believe this is causing my mets to be painless. I'm 58, mine was aggressive G9, merely I spit at information technology. Seven and a half years gets you pretty fed up with the side effects, but they do subside. Except the hot flashes, ugh. Do yourself a big favor, and try to care. Laugh a picayune. I make fun of my girly boobs, it's only a fact of life at present. Expert Luck.

Joe

David20451 profile image

Diagnosed in 2000. Gleason 9. Currently on Xtandi after many other therapies. I've had adept success using Gabapentin to gainsay the hot flashes and dark sweats.

Joelhirsch profile image

thanks. I was on gabapentin for the peripheral neuropathy that came with the chemo. only stayed on it a couple months. didn't like how it affected my thinking process. my docs are talking to each other at present to try and figure out what to give me.

chucko profile image

I accept been using a mixture of almond oil and peppermint oil on the inside of my wrists and the back of my neck at night. Seems to piece of work. Recommended by a menopausal lady friend for hot flashes. Exercise beats the fatigue, ironically. Helps on the weight gain and the mood swings, too.

Joelhirsch profile image

I capeesh all of your replies, truly. Some of the suggestions I've already tried, some are not really feasible to me, every bit I have non retired yet (I look to medically retire the end of this year). it'due south nice to know there's more than than a handful of GS ix plus that go on stayin alive. as i'grand certain each of yous accept experienced, information technology'southward merely very overwhelming at times. and I've barely touched on the pretty bad other side effects I've had/have. glad I'm a fellow member of this group, although equally they say, I wouldn't want to be a member of any club that would be willing to have me every bit a member :)

Me neither..You have a great spirit..Keep it upwards !

It'southward official! Welcome to the guild. Most of united states have these symptoms.I do. .I m on treatments for just ii yrs. I was having a bad time emotionally a twelvemonth. ago .An onocology phycatrist told me Kalonapin for ii wks then lexipro for a calendar month then he would talk to me. I was having suicidal thoughts and taking it all out on my passive married woman.Im so hesitant to have any more than chemicals ..So I refused under stiff advice from my married woman. Skip forrad some other yr and now I all the same fight heavy emotional surges.Some days none, sometimes feeling bad for weeks at a time..This for sure for me is a battle.. I'yard told by many " Yes, have the phycho tropic drugs" and others say "Don't practice it " Keeping effectually positive people and situations is my best way to go along my spirits upward. Now if ane gets trapped in a suicidal or destructive land of mind ,seek help .Hang in in that location and know that y'all are not alone in this at 55.Im 2yrs ahead of you and that's not much ..Only I've read hither of men in their twoscore'south , and so we ar non the youngest nor do we take the worst cases ....About of u.s. tin get depressed.. don't get caught in that location. Find some happiness each 24-hour interval ..Give and receive love. ... may sound corny ,but for me information technology's the best med. We got a puppy ..Hard for me to exist sad or depressed when I'm with 8month old Lulu.. I'thousand also on a test drug , Tak -700... yah! Nosotros know how to have fun ..Skilful luck!

ctarleton profile image

Walking the dog in the park definitely has some healing qualities almost it, with the added benefit of getting out into the beautiful real earth instead of so wrapped up inside one'southward head.

Dr_WHO profile image

Been on Lupron for a little over a year. Take issues thinking clear and go flustered over the smallest of things. What is worse I have very major emotional swings. Talked to a therapist over the phone that works for the insurance company. That did non get well. She focused on if I am suicidal. If I was, I simply would stop the Lupron shots. Started Zytiga on meridian of Lupron about two weeks ago. Now every nighttime I am having very weird dreams (not always bad dreams, just weird). Thinking nearly the dreams during the day is making the other symptoms merely that much worce.

Oh well....

I'm with ya! It'south a roller coaster to be stripped of your hormones..About men don't function well , including me..What a political party..Take care Dr.!

ctarleton profile image

If you are taking the Zytiga with the prescribed Prednisone (or a like corticosteroid drug), that could be the crusade of the weird dreams and thoughts. It is a mutual side effect. (Some have suggested maybe taking information technology in the morning to lessen such sleep-related furnishings.)

Dr_WHO profile image

Thank you. I have been taking Prednisone in the morning. Considering how strong the dreams are, I am glad that I do not accept it at dark.

pcb17 profile image

I'chiliad off the Lupron, but I all the same run into blood in my urine and stool. Does that seem normal?

Consult with a urologist and oncologist for this. It'due south an of import result. Not sure it is related to Lupron only any blood in urine or stool is a definite followup.

Does not seem normal at all!

Terje profile image

I had the same experience with Lupron. In addition to being over-emotional I definitely found my brain functions slowing down and becoming very forgetful (wouldn't remember what I had for breakfast!) and then on.

I switched to Firmagon (Degarelix) and found that to help quite a flake. Even though I have a lot of pain (injection site) for a couple of days I still prefer it to Lupron.

All-time wishes

Terje

Caring7 profile image

Try the antidepressant. My husband finally decided he needed this and it made a HUGE difference! He had to try two. The first one but didn't sit well (this is a typical thing with anti-depressants). He is now taking Lexapro at a low dose. He feels much meliorate and I feel a LOT improve. He is just more than even, more than resilient in dealing with things, much less swing on the moods, non taking anger out on me as much. The prostate drugs cause a male version of menopause, which includes a strong emotional component. (Ask any woman who'south endured menopause.) I would urge you to at least endeavor some medication for depression (and try another 1 if the first one doesn't fit correct), for your own sake (then that you can intendance) and besides for the sake of anyone close to you.

I was and so happy (ok, I almost fell over) when my husband said he wanted to get a psychiatrist referral to effort some antidepressant treatment. (I was thinking this really hard simply not telling him to practice it.) And the results have been actually expert. He's not any different, just able to "roll with things" and non get overwrought about things (niggling things), able to let get, has some more empathy for me, doesn't get as angry (a depression symptom), enjoying life more. BTW - his situation is quite similar to yours -- dx at age 52, phase four, afar mets (no surgery for him), did chemo early (CHAARTED protocol), ran through Casodex pretty speedily, now on Lupron and Xtandi for testerone blocking. Also did Xofigo and Provenge. Great that you lot are in a study that is working physically. So endeavour to go some aid and then you tin can enjoy this do good more.

What is the study you are in?

Best wishes.

Give thanks you. we are debating anti-depressants or non.Glad that y'all had good results.

Caring7 profile image

To all who posted most emotional states on these drugs. Thanks!!!

I posted a reply to help others but got some myself. The descriptions here match what my husband was doing (lashing out , uneven mood, etc.) so reading these posts helped me feel not alone and reassured my perceptions. Information technology's hard every bit the partner bec one is not going through this but one is besides the closest target and when information technology's persistent and bad I commencement thinking that maybe I am a bad person who is torturing my hubby past my mere presence.

This thread volition help remind me - information technology'south not me. Thanks everyone!!

Innocent bystanders = it is not you. Why do we have it out on those that we love ?Dont know, but pray for you and all of our families that witness the weirdness of APC's harshness.

In my mind we all need to give all of our caregivers a large hug. They accept an unbelievable hard job. I just wish that more caregivers post their concerns so that the group could help with the burden.

Delight know that we are all there for you. It is a fact that the burden on family unit and caregivers goes well across the physical needs. Unfortunately it as well covers the emotional. For me the since of frustration, fear and acrimony I feel is made a hundred times worce do to Lupron and like drugs. To be honest, I practise non know how the caregivers do it. I am then thankful that I take the cancer and not my wife. I am non potent enough to be a caregiver.

Mahalo. Appreciate the kind words.

Joelhirsch profile image

At National Cancer Center/National Institute of Wellness, Bethesda, MD. The study includes enzalutamide (Xtandi) and an ongoing serial of live virus immunotherapy injections. Besides, still on Lupron. I'm not sure if the report is withal open, but I believe if you lot're already on enzalutamide and so you're not eligible, just not sure. Best to call NIH and/or visit their website. not sure where you're from merely some of their studies are available only there, and some at NIH approved facilities.

Caring7 profile image

Thanks. Nosotros heard something like this might be evolving so practise well for time to come patients! Nosotros will be sure to at least ask well-nigh this. Nosotros work with a enquiry oncologist in San Francisco so he will be enlightened of the possibilities just good to know some of the details for when nosotros talk to him.

Good luck!

Chazem profile image

Hot flashes accept been controlled with Effexor Forty 37.5 to 75 mg once daily.

I tried Gabapentin titated upward to 300 mg once daily just not as good and I stopped when I got swelling to one leg that was non due to a DVT.

Rexwayne profile image

Well I have been going thrum this going on 13 years now. I'm 63. Last v land four bone cancer. Yea we have emotional swings. I cry at the movies and just out of the blue. Simply is role of who we are now. Motivation is just you make your self exercise stuff. Join a gym and go. Accept the canis familiaris for a walk. Piece of work around the firm doing small chores. Right now I'm painting the within of my house. Very slowly simply it is getting done. Staying active I very of import. I remember that is the real key and information technology helps me with my emotional swings. I also accept anxiety medication, lorazepam helps the most. two mg twice a solar day works for me. Best of luck to yous.

resilient2013 profile image

Hi, I sympathise how you feel, please keep fighting, my husband simply turn 62 terminate of May and was diagnosed with PC malignant neoplasms 2013- whatsoever ways he was using Lupron, he was in this Meds for nearly 2 yrs, but as you he could non bargain with the side effects mood changes, hot flashes later a talk with the Dr he decide to alter it to Zolodex he'due south. Also taking Xtandi, just in March he was diagnosed with phase IV mets in the lungs, the only result with zolodex is just from fourth dimension to fourth dimension he sweats, but no hot flashes, and not other side effects, taking both medicines his PSA .14 and TTRNE is a 40. Promise this help yous,

I'g in a simalar state of being as you and I understand completely how you feel..

BobChanin profile image

After reading these my only advice is to go an orchiectomy. I'one thousand a little calorie-free downstairs but accept bypassed all the Lupron side effects mentioned. (no one knows unless you take your britches down or your married woman tells them!)

I besides chose orchiectomy..This is an option that made sense for me..Not putting any more pharmaceuticals in me and so absolutely nessasary is a better way for me. .I sympathize that for many this is a taboo field of study. Faced with an ugly diagnosis we all make hard choices to extend our quality of life for as long every bit possible. With APC the male ego in some ways must get by the wayside..in order to survive we have many other ways to self identify also our sexually ID. Pride,cocky indulgence , ego all Must die to live with APC. There are many positive attributes in our feminine side..Compassion and dearest are the top two ,in my volume.Good luck with your journeying and cheers for your honesty,,

Johnstonearch profile image

I have been on Cymbalta for the xviii years for low and bone hurting .I take been living with Pca and on Lupron continuously also all that time. I have been on Xtandi now for 3 years at a 1/2 dose. Without the anti-depressant I don't think I would be hither. Go practice as well any it takes. Last night I watched Johnathan Winter's clips and Robin Williams for about 90 minutes my facial cheeks hurt and my ribs were sore but Boy did I have a expert fourth dimension!

BobChanin profile image

My Solution: Orchiectomy. . . . I had many of the symptoms you have with mets all over and over 4 years postal service diagnosis. Your state of affairs sounds like "what accept yous got to loose?" My wife of 41 years was very encouraging and I understand younger men and their wives are hesitant. Thought I would share as this has been a positive experience for united states. Good luck.

BobChanin

Joelhirsch profile image

I don't empathise how that would make a difference. I thought the symptoms were from the lack of hormones.

A choice that we've made that nigh men fear immeasurably..We chose life over ego ..Anoint you and your married woman!!!

wellness profile image

I had hot flashes from hell for over a year until I plant this solution: estradiol and progesterone. Estradiol past itself did non work for me. I am using transdermal creams in the evening. Hot flashes disappeared. Changed my life. The products I apply are Estrogel in 32 dose container, and At present brand natural progesterone cream, bachelor over the counter. This has been a miracle for me.

Jrb12 profile image

Hullo Joel, the hot flashes are abrasive, merely I figure it's a pocket-size price to pay. I seem to get hot flashes when i take the urge to urinate. I don't desire to accept another med. I've tried black cohash, it did goose egg. Now for mood swings, I take Vitamin B12 and B6. This combo really seems to exist beneficial fot me. Information technology's cheap enough to try for a month. God bless. Richard

The same for me ever gotta pee hot flash that my formula also.

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